Waltham, MA

Job Description

My client is expanding and seeks a Director to take on the following tasks:

  • Provide direction and leadership to a team of cancer biologists focused on expanding the DNA Damage Response platform
  • Develop the overall strategy for deploying the DDR platform to advance the drug discovery pipeline
  • Lead a team of scientists in the design, development, and implementation of robust enzyme- and cell-based assays to characterize the effects of lead compounds on DDR pathways
  • Oversee the generation and analysis of high-quality experimental data to identify and confirm the mechanism of action of lead compounds
  • Guide new DDR target identification and validation activities, including CRISPR-based synthetic lethal screens, both internally and through external service providers
  • Collect, analyze, and summarize data for presentations, reports, publications, and patents
  • Interact cross-functionally and provide scientific leadership on preclinical project teams
  • Maintain an up-to-date understanding of new technologies and relevant scientific advances in cancer and DDR biology from literature, scientific meetings, and professional network


The ideal candidate will possess the following qualities:

  • PhD and extensive experience in DDR biology and small molecule drug discovery
  • Hands-on experience with enzyme- and cell-based assays typically used to study DDR biology, DNA repair, and replication stress
  • Knowledge of the current therapeutic landscape and target opportunities in the DDR space
  • Demonstrated ability to mentor and manage team of cancer biologists
  • Experience performing and interpreting CRISPR-based synthetic lethal screens
  • Experience managing external scientific collaborations
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